Quick Answer: How is topiramate metabolized?

Topiramate is quickly absorbed after oral use. Most of the drug (70%) is later excreted in the urine unchanged; therefore, it requires dosage reduction in the setting of renal insufficiency. The remainder is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation.

Does Topamax hurt your liver?

Topiramate is thought to be rarely associated with liver injury and by and large known to cause liver toxicity in conjunction with other anticonvulsants.

Does Topamax affect kidneys?

Topomax can cause damage to kidney tubules that result in a failure to eliminate acid from the body. This may lead to kidney stones and other forms of damage to the kidneys over time. Topomax also has side effects that may be associated with weight loss and suppression of appetite.

Why is low carb bad while taking Topamax?

Topiramate can increase body temperature and decrease sweating, leading to life-threatening dehydration (especially in children). Avoid the use of a ketogenic or “ketosis” diet (high in fat, low in carbohydrates) while you are taking topiramate. Topiramate may cause blurred vision or impair your thinking or reactions.

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Do you gain weight back after stopping Topamax?

Conclusions: Loss of body weight is a reversible effect, which at 6 months after TPM discontinuation shows a clear trend to return to baseline values. HOMA-IR is the only predictive factor of weight regain.

How do you feel on Topamax?

What are the side effects of Topamax?

  1. tingling of the arms and legs (paresthesia)
  2. not feeling hungry.
  3. weight loss.
  4. speech problems.
  5. fatigue.
  6. dizziness or sleepiness.
  7. slow reactions (psychomotor slowing)
  8. nervousness.

12 мар. 2019 г.

Does Topamax make you pee a lot?

Tell your doctor if you have unlikely but serious side effects of Topamax including: signs of kidney stones (such as severe back/side/abdominal/groin pain, fever, chills, painful/frequent urination, bloody/pink urine);

Does Topamax affect potassium levels?

Topiramate belongs to the new class of neuromodulators, which has carbonic anhydrase inhibitor activity and been associated with renal calculi. It has also been shown to cause renal potassium wasting; however, it is generally clinically insignificant.

What can you not take with topiramate?

People should not drink alcohol or take sedatives or tranquilizers, such as Valium and Xanax, while taking Topamax. Topamax suppresses the activity of the enzyme, carbonic anhydrase, in the body.

Does Topamax cause brain fog?

Patients often experience brain fog, or a decrease in cognition, when beginning Topamax.

Can I have a glass of wine with Topamax?

You should avoid alcoholic beverages while taking other forms of Topiramate. Alcohol can affect seizure control and interfere with the drug treatment and may increase the risk of serious side effects. Decreased alertness, drowsiness, falls, or other side effects may occur.

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What is the average weight loss on Topamax?

Results: All 5 patients had a good response to treatment at a mean topiramate dose of 195 mg/day (range, 100–375 mg/day). All patients lost a substantial amount of weight on topiramate treatment. The average weight loss was 22 lb (10 kg; range, 8–56 lb [4–25 kg]).

Can you drink caffeine with Topamax?

topiramate oral increases and caffeine oral decreases sedation and drowsiness. Monitor CloselyModify Therapy/Monitor Closely.

What mg of Topamax causes weight loss?

Results from the trials showed that after 1 year of treatment with the recommended dose (7.5 mg phentermine, 46 mg of topiramate), patients experienced an average weight loss of 6.7%, and those who were treated with the highest daily dose (15 mg phentermine, 92 mg topiramate) had an average weight loss of 8.9%.

Can you gain weight on Topamax?

This meta-analysis found that topiramate was associated with weight loss or attenuated weight gain when compared to controls (−2.83 kg; 95% CI, −4.62 to −1.03).

How long does Topamax withdrawal last?

6) Topiramate (Topamax)

Instead, taper your dosage gradually over 2 to 8 weeks to prevent rebound effects.